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FAM98A

Family with sequence similarity 98, member A, or FAM98A, is a gene that in the human genome encodes the FAM98A protein. FAM98A has two paralogs in humans, FAM98B and FAM98C. All three are characterized by DUF2465, a conserved domain shown to bind ...

                                               

FANCL

The clinical phenotype of mutational defects in all Fanconi anemia FA complementation groups is similar. This phenotype is characterized by progressive bone marrow failure, cancer proneness and typical birth defects. The main cellular phenotype i ...

                                               

FARP2

Model organisms have been used in the study of FARP2 function. A conditional knockout mouse line, called Farp2 tm1aKOMPWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ge ...

                                               

FARSB

Phenylalanyl-tRNA synthetase beta chain is an enzyme that in humans is encoded by the FARSB gene. This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIC subfamily. This enzyme consists of regulatory be ...

                                               

FBXO11

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs SKP1-cullin-F ...

                                               

FEZ2

Fasciculation and elongation protein zeta-2 is a protein that in humans is encoded by the FEZ2 gene. This gene is the ortholog of C. elegans UNC-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Other orth ...

                                               

Fibroblast activation protein, alpha

Fibroblast activation protein alpha also known as prolyl endopeptidase FAP is an enzyme that in humans is encoded by the FAP gene. Shed-endopeptidase FAP is a membrane-bound 170 KDA gelatinase. It was independently identified as a surface glycopr ...

                                               

FKBP1B

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase th ...

                                               

FMNL2

Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 FRL3 protein 1092 amino acids-NCBI Reference Sequence: NP_443137.2 is regulated through autoinhibition, and may bec ...

                                               

G6PC2

This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeoge ...

                                               

GAD1

Glutamate decarboxylase 1, also known as GAD1, is a human gene. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in Insulin-dependent diabetes. The enzyme encoded is responsible for the acce ...

                                               

GAL3ST2

Galactose-3-O-sulfotransferase 2 is an enzyme that in humans is encoded by the GAL3ST2 gene. This gene encodes a member of the galactose-3-O-sulfotransferase protein family. The product of this gene catalyzes sulfonation by transferring a sulfate ...

                                               

Galactose mutarotase

Galactose mutarotase is a human enzyme that converts alpha-aldose to the beta-anomer. It belongs to family of aldose epimerases.

                                               

GALNT3

Polypeptide N-acetylgalactosaminyltransferase 3 is an enzyme that in humans is encoded by the GALNT3 gene. This gene encodes UDP-GalNAc transferase 3, a member of the polypeptide GalNAc GalNAc-T transferase family. This family transfers an N-acet ...

                                               

GALNT13

Polypeptide N-acetylgalactosaminyltransferase 13 is an enzyme that in humans is encoded by the GALNT13 gene. In GALNT13 protein is a member of the UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase GalNAcT, EC 2.4.1. ...

                                               

GALNT14

Polypeptide N-acetylgalactosaminyltransferase 14 is an enzyme that in humans is encoded by the GALNT14 gene. GALNT14 EU 2.4.1.41 belongs to a large subfamily of glycosyltransferases residing in the Golgi apparatus. GALNT enzymes catalyze the firs ...

                                               

Gamma-glutamyl carboxylase

Gamma-glutamyl carboxylase is an enzyme that catalyzes the posttranslational modification of vitamin K-dependent proteins. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential f ...

                                               

GBX2

Gastrulation Brain Homeobox 2 GBX2 is a homeobox gene involved in the normal development of rhombomeres 1-3 which is the mid/hindbrain region. This gene is a dosage dependent transcription factor involved in the regulation of proper expression of ...

                                               

GCC2

GRIP and coiled-coil domain-containing protein 2 is a protein that in humans is encoded by the GCC2 gene. The protein encoded by this gene is a peripheral membrane protein localized in the TRANS-Golgi network. It is sensitive to brefeldin A. This ...

                                               

GCFC2

GC-rich sequence DNA-binding factor is a protein that in humans is encoded by the GCFC2 gene. The first mRNA transcript isolated for this gene is part of an artificial Chimera derived from two distinct gene transcripts and a primer used in the cl ...

                                               

GCS1

Mannosyl-oligosaccharide glucosidase is an enzyme that in humans is encoded by the MOGS gene. Glucosidase I is the first enzyme in the N-linked oligosaccharide processing path. GCS1 cleaves the distal alpha-1.2-linked glucose residue from the Glc ...

                                               

Gem-associated protein 6

Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.The gem-associated proteins are those found in the gems of Cajal bodies.

                                               

GEN1, Holliday junction 5 flap endonuclease

This gene encodes a member of the Rad2/xeroderma pigmentosum group G nuclease family, whose members are characterized by N-terminal and internal xeroderma pigmentosum group G nuclease domains followed by helix-hairpin-helix domains and disordered ...

                                               

GFPT1

Glucosamine - fructose-6-phosphate aminotransferase isomerizing 1 is an enzyme that in humans is encoded by the GFPT1 gene. Glutamine-fructose-6-phosphate transaminase 1 is the first and limiting enzyme of the hexosamine path. GFAT controls the f ...

                                               

GKN1

Gastrokine-1 is a protein that in humans is encoded by the GKN1 gene. The protein encoded by this gene is down-regulated in human cancer tissues of the stomach compared with the normal gastric mucosa.

                                               

Glucokinase regulator

This gene encodes a protein belonging to the GCKR subfamily of the SIS sugar isomerase family of proteins. The gene product is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an ...

                                               

Glutaminase

Glutaminase is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells. Glutaminase catalyzes the following reaction: Glutamine H2O → glutamate пн3

                                               

Glypican 1

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family GRIPS contain a core ...

                                               

GMCL1

This gene encodes a nuclear envelope protein that appears to be involved in spermatogenesis, either directly or by influencing genes that play a more direct role in the process. This multi-exon locus is the homolog of the mouse and drosophila ger ...

                                               

GNLY

Granulysin, also known as GNLY, is a protein which in humans is encoded by the GNLY gene. It is also known as NK-lysin after NK cells, the cattle ortholog is sometimes referred to as Bo-lysin. Granulysin released by cytotoxic T-cells and NK-cells ...

                                               

GPATCH11

GPATCH11 is a protein that in humans is encoded by the G-patch domain containing protein 11 gene. The gene has four transcript variants encoding two functional protein isoforms and is expressed in most human tissues. The protein has been found to ...

                                               

Grancalcin

Grancalcin is a protein that in humans is encoded by the GCA gene. This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the Penta-EF-hand subfamily of proteins that includes Sorin, cal ...

                                               

GRASP55

Golgi reassembly-stacking protein of 55 kDa also known as golgi reassembly-stacking protein 2 is a protein that in humans is encoded by the GORASP2 gene. It was identified by its homology with GRASP65 and the proteins amino acid sequence was dete ...

                                               

GRB14

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene. The product of this gene belongs to a small family of adapter proteins, which are known to interact with several receptor tyrosine kinases and signa ...

                                               

GREB1

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants ...

                                               

HAAO

3-hydroxyanthranilate 3.4-dioxygenase is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction 3-hydroxyanthranilate + O 2 ⇌ {\displaystyle \rightleftharpoons } 2-amino-3-carboxymuconate semialdehyde Thus, the two substrates of ...

                                               

HADHB

Trifunctional enzyme subunit beta, mitochondrial also known as 3-ketoacyl-CoA thiolase, acetyl-CoA acyltransferase, or beta-ketothiolase is an enzyme that in humans is encoded by the HADHB gene. HADHB is a subunit of the mitochondrial trifunction ...

                                               

HAT1

The protein encoded by this gene is a type B histone acetyltransferase that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chai ...

                                               

HDAC4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by th ...

                                               

HECW2

Model organisms have been used in the study of HECW2 function. A conditional knockout mouse line called Hecw2 tm1aEUCOMMWtsi was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen ...

                                               

Hepatic fructokinase

Hepatic fructokinase is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate. ATP + ⟶ {\displaystyle \longrightarrow } ADP + ATP + D-fructose → ADP + D-fructose-1-phosphate

                                               

HK2

Hexokinase 2 also known as HK2 is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexoki ...

                                               

HNRNPLL

HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 PTPRC, MIM 151460, a tyrosine phosphatase essential for T-cell development and activation.

                                               

HRB (gene)

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhanc ...

                                               

HS1BP3

The protein encoded by this gene shares similarity with mouse Hs1bp3, an Hcls1-interacting protein that may be involved in lymphocyte activation. HS1BP3 binds members of the 14-3-3 family of proteins that are highly expressed in motor neurons and ...

                                               

HtrA serine peptidase 2

Serine protease HTRA2, mitochondrial is an enzyme that in humans is encoded by the HTRA2 gene. This protein is involved in caspase-dependent apoptosis and in Parkinsons disease.

                                               

IDH1

Isocitrate dehydrogenase 1, soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct su ...

                                               

IGFBP5

Insulin-like growth factor-binding protein 5 is a protein that in humans is encoded by the IGFBP5 gene. An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.

                                               

IL1A

Interleukin 1 alpha also known as hematopoietin 1 is a cytokine of the interleukin 1 family that in humans is encoded by the IL1A gene. In general, Interleukin 1 is responsible for the production of inflammation, as well as the promotion of fever ...

                                               

IL1F10

Interleukin-1 family member 10 is a protein that in humans is encoded by the IL1F10 gene. The protein encoded by this gene is a member of the interleukin 1 family of cytokines. This gene and eight other interleukin 1 family genes form a cytokine ...

Encyclopedic dictionary

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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