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GPD1L

GPD1L is a human gene. The protein encoded by this gene contains a glycerol-3-phosphate dehydrogenase motif and shares 72% sequence identity with GPD1.

                                               

GPX1

Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydr ...

                                               

GRASP65

Golgi reassembly-stacking protein of 65 kDa also known as Golgi reassembly-stacking protein 1 is a protein that in humans is encoded by the GORASP1 gene.

                                               

GSK3B

Glycogen synthase kinase 3 beta, also known as GSK3B, is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is encoded by the GSK-3β gene. Abnormal regulation and expression of GSK3β is associated with an increased suscept ...

                                               

H1FOO

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the fou ...

                                               

H1FX

Histone H1x is a protein that in humans is encoded by the H1FX gene. Histones-basic nuclear proteins that are responsible for the structure of the nucleosomes of the chromosomal fiber in eukaryotes. The threads consist of approximately 146 BP of ...

                                               

HDAC11

Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. This is the only class IV HDAC because it is not highly homologous with Rpd3 or hda1 of ...

                                               

HIGD1A

HIG1 domain family member 1A, also known as hypoglycemia/hypoxia inducible mitochondrial protein1-a and hypoxia induced gene 1, is a protein that in humans is encoded by the HIGD1A gene on chromosome 3. This protein promotes mitochondrial homeost ...

                                               

Histamine H1 receptor

The H 1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, in the h ...

                                               

Histone H4

Histone H4 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H4 is involved with the structure of the nucleosome of the beads on a str ...

                                               

HLTF

This gene encodes a member of the SWI/SNF family. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein co ...

                                               

Homogentisate 1.2-dioxygenase

Homogentisate 1.2-dioxygenase is an enzyme which catalyzes the conversion of homogentisate to 4-maleylacetoacetate. Homogentisate 1.2-dioxygenase or HGD is involved in the catabolism of aromatic rings, more specifically in the breakdown of the am ...

                                               

HPS3

Hermansky–Pudlak syndrome 3 protein is a protein that in humans is encoded by the HPS3 gene. This gene encodes a protein containing a potential clathrin-binding motif, forecast dileucine signals, and tyrosine sorting signals for targeting the ves ...

                                               

HYAL1

This gene encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentia ...

                                               

HYAL2

Hyaluronidase-2 is an enzyme that in humans is encoded by the HYAL2 gene. This gene encodes a protein that is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the ex ...

                                               

HYAL3

Hyaluronidase-3 is an enzyme that in humans is encoded by the HYAL3 gene. This gene encodes a protein that is similar in structure to hyaluronidases. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the ex ...

                                               

IFT80

Intraflagellar transport protein 80 homolog, also known as WD repeat-containing protein 56, is a protein that in humans is encoded by the IFT80 gene.

                                               

IGF2BP2

Insulin-like growth factor 2 mRNA-binding protein 2 is a protein that in humans is encoded by the IGF2BP2 gene. This gene encodes a member of the IGF-II mRNA-binding protein IMP of the family. The protein encoded by this gene contains several dom ...

                                               

IHPK1

Inositol hexakisphosphate kinase 1 is an enzyme that in humans is encoded by the IP6K1 gene. This gene encodes a protein that belongs to the Inositol-phosphokinase the family of IPK. This protein is probably responsible for the conversion of Inos ...

                                               

IHPK2

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene. This gene encodes a protein that belongs to the Inositol-phosphokinase the family of IPK. This protein is probably responsible for the conversion of Inos ...

                                               

IL1RAP

Interleukin-1 receptor accessory protein is a protein that in humans is encoded by the IL1RAP gene. Interleukin-1 induces synthesis of acute phase proteins and proinflammatory cytokines during infection, tissue damage, or stress, by forming a com ...

                                               

IL12A

This gene encodes a subunit of the cytokine Interleukin 12 IL-12 that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this ...

                                               

IMPDH2

IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-depende ...

                                               

Inosine-5′-monophosphate dehydrogenase

Inosine-5′-monophosphate dehydrogenase is a purine biosynthetic enzyme that catalyzes the nicotinamide adenine dinucleotide -dependent oxidation of inosine monophosphate to xanthosine monophosphate, the first committed and rate-limiting step towa ...

                                               

Integrin alpha 9

This gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta ...

                                               

Interleukin 5 receptor alpha subunit

Interleukin 5 receptor, alpha also known as CD125 is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.

                                               

Interleukin 12

Interleukin 12 is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells in response to antigenic stimulation. IL-12 belongs to the family of interleukin-12. IL-12 family is unique ...

                                               

Interleukin-5 receptor

The interleukin-5 receptor is a type I cytokine receptor. It is a heterodimer of the interleukin 5 receptor alpha subunit and CSF2RB. The Il-5 receptor Il-5R belongs to the type I cytokine receptor family and is a heterodimer composed of two poly ...

                                               

Interleukin-17 receptor

Interleukin-17 receptor is a cytokine receptor which belongs to new subfamily of receptors binding proinflammatory cytokine interleukin 17A, a member of IL-17 family ligands produced by T helper 17 cells. IL-17R family consists of 5 members: IL-1 ...

                                               

IQSEC1

IQ motif and SEC7 domain-containing protein 1 also known as ARF-GEP 100 is a protein that in humans is encoded by the IQSEC1 gene.

                                               

IRAK2

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor IL1R upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulat ...

                                               

KIAA1257

KIAA1257 is a protein that in humans is encoded by the KIAA1257 gene. KIAA1257 has been shown to be involve with activation of genes involved in sex determination.

                                               

KIAA1524

Protein phosphatase 2A PP2A is a trimeric serine-threonine phosphatase consisting of a catalytic C-subunit PP2Ac, a scaffolding A-subunit and various regulatory B-subunits. Importantly, it has been estimated that collectively PP2A complexes can d ...

                                               

KIF15

Kinesin family member 15 is a protein that in humans is encoded by the KIF15 gene. This gene encodes a protein motor, which is part of the kinesin superfamily. KIF15 supports half spindle separation by opposing forces generated by other motor pro ...

                                               

Laminin, beta 2

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, sig ...

                                               

LIPH

Lipase member H is an enzyme that in humans is encoded by the LIPH gene. This gene encodes a membrane-bound member of the family of mammalian triglyceride lipase. It catalyzes the production of 2-acyl lysophosphatidic acid LPA, which is a lipid m ...

                                               

LPP (gene)

Lipoma-preferred partner is a subfamily of LIM domain proteins that are characterized by an N-terminal proline rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involve ...

                                               

LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a protein that in humans is encoded by the LRIG1 gene. It encodes a transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR family and with ...

                                               

MAGI1

The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue MAGUK family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell–c ...

                                               

MAP3K13

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase contains a dual leucine-zipper motif, and has been shown to form dimers/oligomers through its leucine-zipper motif. This kinase can phosphorylate ...

                                               

Map44

Mannose-binding lectin-associated protein of 44 kDa is a protein arising from the human MASP1 gene. MASP-1, MASP-3 and MAp44 are alternative splice products of the MASP1 gene. MAp44 has been suggested to act as a competitive inhibitor of lectin p ...

                                               

MAPKAPK3

This gene encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase MAP kinase- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases ERKs, act as a ...

                                               

MASP1 (protein)

Mannan-binding lectin serine protease 1 also known as mannose-associated serine protease 1 is an enzyme that in humans is encoded by the MASP1 gene. MASP-1 is involved in the lectin route of complement system and is responsible for cleaving C4 an ...

                                               

MBD4

Human MBD4 protein has 580 amino acids with a methyl-CpG-binding domain at amino acids 82–147 and a C-terminal DNA glycosylase domain at amino acids 426–580. These domains are separated by an intervening region that interacts with UHRF1, an E3 ub ...

                                               

MCM2

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins MCM that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component ...

                                               

MED12L

The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basa ...

                                               

Metabotropic glutamate receptor 2

Metabotropic glutamate receptor 2 is a protein that, in humans, is encoded by the GRM2 gene. mGluR2 is a G protein-coupled receptor that couples with the Gi alpha subunit. The receptor functions as an autoreceptor for glutamate, that upon activat ...

                                               

Metabotropic glutamate receptor 7

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be ...

                                               

Methylcrotonyl-CoA carboxylase

Methylcrotonyl CoA carboxylase is a biotin-requiring enzyme located in the mitochondria. MCC uses bicarbonate as a carboxyl group source to catalyze the carboxylation of a carbon adjacent to a carbonyl group performing the fourth step in processi ...

                                               

MicroRNA 138-1

microRNAs miRNAs are short 20-24 nt non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymer ...

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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