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UBE2N

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiqui ...

                                               

ULK1

ULK1 is an enzyme that in humans is encoded by the ULK1 gene. UNC-51 like autophagy activating kinase ULK1 / 2 are two similar isoforms of the enzyme which in humans is encoded in ULK1 / 2 genes. It kinase, which is involved in autophagy, particu ...

                                               

Uracil-DNA glycosylase

Uracil-DNA glycosylase, also known as UNG or UDG, is an enzyme. The human gene is well researched and orthologs exist ubiquitously among prokaryotes and eukaryotes and even in some DNA viruses. The first uracil DNA-glycosylase was isolated from E ...

                                               

VAMP1

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the ...

                                               

Vesicular glutamate transporter 3

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft.

                                               

VPS29

VPS29 belongs to a group of genes coding for vacuolar protein sorting VPS proteins that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene, Vps29, is a component of a large multime ...

                                               

WIF1

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.

                                               

WNT1

Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in s ...

                                               

WNT5B

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several develop ...

                                               

WNT10B

Protein Wnt-10b is a protein that in humans is encoded by the WNT10B gene. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several deve ...

                                               

XPOT

Exportin-T is a protein that in humans is encoded by the XPOT gene. This gene encodes a protein belonging to the RAS-GTP-ASE family exportin that exports tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once e ...

                                               

YAF2

YY1-associated factor 2 is a protein that in humans is encoded by the YAF2 gene. The protein encoded by this gene interacts with yy1 install on protein zinc-finger involved in negative regulation of muscle-limitation genes. This gene product cont ...

                                               

ABCC4

ATP-binding cassette sub-family C member 4, also known as the multidrug resistance-associated protein 4 or multi-specific organic anion transporter B, is a protein that in humans is encoded by the ABCC4 gene. ABCC4 acts as a regulator of intracel ...

                                               

ADPRHL1

ADP-ribosylation is a reversible posttranslational modification used to regulate protein function. ADP-ribosyltransferases see ART1, MIM 601625 transfer ADP-ribose from NAD+ to the target protein, and ADP-ribosylhydrolases, such as ADPRHL1, rever ...

                                               

AKAP11

The A-kinase anchor proteins AKAPs are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A PKA and confining the holoenzyme to discrete locations within the cell. This ...

                                               

ARGLU1

Arginine and glutamate-rich protein 1 is a protein that in humans is encoded by the ARGLU1 gene located at 13q33.3. The protein product of this gene was proposed as MED1-interacting protein required for estrogen-dependent gene transcription and c ...

                                               

ARHGEF7

Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene. ARHGEF7 is widely known as S. 21 - a ctivated protein kinase e x change ratio of alpha -, beta-Pix and ßPIX because it was identified by binding ...

                                               

ATP12A

The protein encoded by this gene belongs to the family of P-type cation transport ATPases. This gene encodes a catalytic subunit of the ouabain-sensitive H + /K + -ATPase that catalyzes the hydrolysis of ATP coupled with the exchange of H + and K ...

                                               

CARKD

Carbohydrate kinase domain containing protein, encoded by CARKD gene, is a human protein of unknown function. The CARKD gene encodes proteins with a predicted mitochondrial propeptide, a signal peptide or neither of them. Confocal microscopy anal ...

                                               

CDC16

This gene encodes a component protein of the APC complex, which is composed of eight proteins and functions as a protein ubiquitin ligase. The APC complex is a cyclin degradation system that governs exit from mitosis. Each component protein of th ...

                                               

CENPJ

Centromere protein J is a protein that in humans is encoded by the CENPJ gene. It is also known as centrosomal P4.1-associated protein. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and norm ...

                                               

CHAMP1

Chromosome alignment-maintaining phosphoprotein 1 also known as zinc finger protein 828 is a protein that in humans is encoded by the CHAMP1 gene.

                                               

CKAP2

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene. The human CKAP2 gene on cDNA of which is known as LB1 In, is a cytoskeleton-associated proteins involved in the development of mitosis. Its high transcrip ...

                                               

CLN5

Ceroid-lipofuscinosis neuronal protein 5 is a protein that in humans is encoded by the CLN5 gene. Neuronal ceroid-lipofuscinoses NCL or CLN is a group of autosomal recessive, progressive encephalopathies in children. They are characterized by psy ...

                                               

COG3

Conserved oligomeric Golgi complex subunit 3 is a protein that in humans is encoded by the COG3 gene. The protein encoded by this gene has similarity to a yeast protein. This seems to be a part of a peripheral membrane protein complex localized o ...

                                               

Collagen, type IV, alpha 1

Collagen alpha-1 chain is a protein that in humans is encoded by the COL4A1 gene on chromosome 13. It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in angiogenesis. Mutation ...

                                               

Collagen, type IV, alpha 2

Collagen alpha-2 chain is a protein that in humans is encoded by the COL4A2 gene. This gene encodes one of six subunits of type IV collagen, the main structural component of the basement membrane. The C-terminal part of the protein, known as cans ...

                                               

Cyclin A1

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic c ...

                                               

DACH1

Dachshund homolog 1, also known as DACH1, is a protein which in humans is encoded by the DACH1 gene. DACH1 has been shown to interact with Ubc9, Smad4, and NCoR.

                                               

DIS3

Exosome complex exonuclease RRP44 or Dis3 is an enzyme that in humans is encoded by the DIS3 gene. Its protein product is an RNase enzyme homologous to the yeast protein Rrp44, and can be part of the exosome complex in the nucleus of eukaryotic c ...

                                               

Dopachrome tautomerase

Dopachrome tautomerase, also known as DCT, is a human gene. Its expression is regulated by the microphthalmia-associated transcription factor.

                                               

Ecto-nox disulfide-thiol exchanger 1

Electron transport pathways are generally associated with mitochondrial membranes, but non-mitochondrial pathways are also biologically significant. Plasma membrane electron transport pathways are involved in functions as diverse as cellular defe ...

                                               

Ephrin B2

This gene encodes a member of the ephrin EPH family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous s ...

                                               

Epithelial stromal interaction 1

The protein encoded by this gene has been shown to promote tumor invasion and metastasis in some invasive cancer cells when overexpressed. Expression of this gene has been shown to be upregulated by direct binding of the Kruppel like factor 8 pro ...

                                               

Factor VII

Factor VII is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme of the serine protease class. A recombinant form of human factor VIIa has U.S. Food and Drug Administration approval for uncontrolled bleeding ...

                                               

Factor X

Factor X, also known by the eponym Stuart–Prower factor, is an enzyme of the coagulation cascade. It is a serine endopeptidase. Factor X is synthesized in the liver and requires vitamin K for its synthesis. Factor X is activated by hydrolysis, in ...

                                               

FARP1

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene. This gene was originally isolated through subtractive hybridization in conjunction with its increased expression in differentiated c ...

                                               

FBXL3

FBXL3 is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3. FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex. In FBXL3 protein is involved in negativ ...

                                               

FGF9

The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic developme ...

                                               

FGF14

Fibroblast growth factor 14 is a protein that in humans is encoded by the FGF14 gene. The protein encoded by this gene is a member of a family of fibroblast growth factor FGF. The FGF family members possess broad mitogenic and survival activities ...

                                               

FOXO1

Forkhead box protein O1 also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin ...

                                               

FREM2

FRAS1-related extracellular matrix protein 2 is a protein that in humans is encoded by the FREM2 gene. This gene encodes a membrane protein that belongs to the FRAS1 family. This extracellular matrix protein believed to be necessary to maintain t ...

                                               

Glypican 5

Glypican-5 is a protein that in humans is encoded by the GPC5 gene. Cell surface proteoglycans heparansulfate consist of a membrane-associated protein core substituted with a variable number heparansulfate the chain. Members of the glypican-relat ...

                                               

Glypican 6

Glypican-6 is a protein that in humans is encoded by the GPC6 gene. In glypicans contain a family of glycosylphosphatidylinositol-anchored proteoglycans heparansulfate. In glypicans have been implicated in control of growth and cell division. Gly ...

                                               

IFT88

This gene encodes a member of the tetratrico peptide repeat TPR family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mut ...

                                               

Integrin subunit beta like 1

This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants.

                                               

INTS6

Integrator complex subunit 6 is a protein that in humans is encoded by the INTS6 gene. Dead box proteins, characterized by conservative motif ASP-STU-Ala-ASP, dead putative RNA helicase. The protein encoded by this gene is a dead box protein that ...

                                               

IPO5

Nuclear transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal NLS requires the NLS import receptor, a hetero ...

                                               

IRS2

This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases an ...

                                               

ITM2B

Integral membrane protein 2B is a protein that in humans is encoded by the ITM2B gene. ITM2B or BRI2 is a gene located on chromosome 13. Gene connected to a family of Danish dementia and familial British dementia causing amyloid and pre-filbrilla ...

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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