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MLST8

Target of rapamycin complex subunit LST8, also known as mammalian lethal with SEC13 protein 8 or TORC subunit LST8 or G protein beta subunit-like, is a protein that in humans is encoded by the MLST8 gene. It is a subunit of both mTORC1 and mTORC2 ...

                                               

MMP2

72 kDa type IV collagenase also known as matrix metalloproteinase-2 and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.

                                               

MMP25

Matrix metalloproteinase-25 is an enzyme that in humans is encoded by the MMP25 gene. Proteins of the matrix metalloproteinase of MMP family, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic ...

                                               

MYH11

Myosin-11 is a smooth muscle myosin belonging to the myosin heavy chain family. Myosin-11 is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. This is the main contract ...

                                               

MYLK3

Phosphorylation of cardiac myosin heavy chains see MYH7B and light chains see MYL2 by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.

                                               

NAD(P)H dehydrogenase (quinone 1)

NADH dehydrogenase 1 is an enzyme that in humans is encoded by the NQO1 gene. This protein-coding gene is a member of the NADH dehydrogenase family and encodes a 2-electron reductase. This FAD-binding protein forms homodimers and performs two-ele ...

                                               

NME4

The nucleoside diphosphate NDP kinases EC 2.7.4.6 are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of th ...

                                               

NOD2

Nucleotide-binding oligomerization domain-containing protein 2, also known as caspase recruitment domain-containing protein 15 or inflammatory bowel disease protein 1, is a protein that in humans is encoded by the NOD2 gene located on chromosome ...

                                               

NPRL3

NPRL3 is a human protein of poorly understood function but has been associated with cancer. The most important functions attributed to Nprl3 today in the framework of the GATOR1 complex DEPDC5 and NPRL2, which inhibits the mechanistic target rapa ...

                                               

NPW

Neuropeptide W is a protein that in humans is encoded by the NPW gene. The NPW neuropeptide W is an endogenous peptide ligand for GPR8 MIM 600731, and the G protein-coupled receptors.

                                               

NTHL1

Endonuclease III-like protein 1 is an enzyme that in humans is encoded by the NTHL1 gene. As reviewed by Lee et al. NTHL1 is a bifunctional DNA glycosylase associated with the beta-elimination activity. NTHL1 usually is responsible for removal of ...

                                               

NUBP2

Nucleotide-binding protein 2 also known as cytosolic Fe-S cluster assembly factor NUBP2 is a protein that in humans is encoded by the NUBP2 gene. NUBP2 gene is a member of the NUBP / MRP subfamily of ATP-binding proteins. There are two types in e ...

                                               

NUDT21

Cleavage and polyadenylation specificity factor subunit 5 is an enzyme that in humans is encoded by the NUDT21 gene. It belongs to the Nudix family of hydrolases. The protein encoded by this gene is one subunit of a cleavage factor im complex req ...

                                               

OGFOD1

Model organisms have been used in the study of OGFOD1 function. A conditional knockout mouse line, called Ogfod1 tm1aKOMPWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ...

                                               

OR2C1

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene. Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell. In the olfactory receptor pr ...

                                               

ORC6

The origin recognition complex ORC is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and ...

                                               

PALB2

This gene encodes a protein that functions in genome maintenance double strand break repair. This protein binds to and colocalizes with the breast cancer 2 early onset protein BRCA2 in nuclear foci and likely permits the stable intranuclear local ...

                                               

PAM16

Mitochondrial import inner membrane translocase subunit TIM16 also known as presequence translocated-associated motor subunit PAM16, mitochondria-associated granulocyte macrophage CSF-signaling molecule, or presequence translocated-associated mot ...

                                               

Paraplegin

The SPG7 gene contains 21 exons and encodes for a protein that is approximately 88 kDa in size. Two transcript variants encoding distinct isoforms have been identified for this gene. SPG7 structure solved by x-ray diffraction analysis showed that ...

                                               

PARD6A

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 PDZ domain and a semi-Cdc42/Rac interactive binding CRIB domain. This cell membrane protein is involved in asymmetrical cell division and cell polarizatio ...

                                               

Phosphoinositide-dependent kinase-1

In the field of biochemistry, PDPK1 refers to the protein 3-phosphoinositide-dependent protein kinase-1, an enzyme which is encoded by the PDPK1 gene in humans. It is implicated in the development and progression of melanomas.

                                               

PIGQ

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q is an enzyme that in humans is encoded by the PIGQ gene. This gene is involved in the first step in glycosylphosphatidylinositol GPI-anchor biosynthesis. In the GPI anchor is a glycol ...

                                               

PKMYT1

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase also known as Myt1 kinase is an enzyme that in humans is encoded by the PKMYT1 gene. The moment 1 is an enzyme in the Wee1 family in vertebrates. The wee 1 family include ...

                                               

PLCG2

Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of th ...

                                               

PLK1

Serine/threonine-protein kinase PLK1, also known as polo-like kinase 1 or serine/threonine-protein kinase 13, is an enzyme that in humans is encoded by the PLK1 gene.

                                               

PMM2

Phosphomannomutase 2 catalyzes the isomerization of mannose 6-phosphate to mannose 1-phosphate. Mannose 1-phosphate is a precursor to GDP-mannose necessary for the synthesis of dolichol-P-oligosaccharides. Mutations in the gene have been shown to ...

                                               

POLR2C

This gene encodes the third largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymeras ...

                                               

POLR3K

DNA-directed RNA polymerase III subunit RPC10 is an enzyme that in humans is encoded by the POLR3K gene. This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for creating transfer and small ribosomal RNAS ...

                                               

Poly(A)-specific ribonuclease

Poly-specific ribonuclease, also known as polyadenylate-specific ribonuclease or deadenylating nuclease, is an enzyme that in humans is encoded by the PARN gene.

                                               

PRKCB1

Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene. Protein kinases with PKC is a family of serine-and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. The P ...

                                               

Procollagen peptidase

Procollagen peptidase is an endopeptidase involved in the processing of collagen. The proteases removes the terminal peptides of the procollagen. Deficiency of these enzymes leads to dermatosparaxis or Ehlers–Danlos syndrome. The enzyme is presen ...

                                               

PRSS8

Prostasin is a protein that in humans is encoded by the PRSS8 gene. This gene encodes a trypsinogen which is a member of the trypsin family of serine proteases. This enzyme is expressed in the epithelium of the prostate gland and is one of severa ...

                                               

PRSS22

Brain-specific serine protease 4, also known as serine protease 22 or tryptase epsilon, is an enzyme that in humans is encoded by the PRSS22 gene. This gene encodes a member of the trypsin family of serine proteases. The enzyme is expressed in th ...

                                               

PSMB10

Proteasome subunit beta type-10 as known as 20S proteasome subunit beta-2i is a protein that in humans is encoded by the PSMB10 gene. This protein plays an important role in the immune system in the framework of the immunoproteasome, which is pri ...

                                               

PSMD7

26S proteasome non-ATPase regulatory subunit 7, also known as 26S proteasome non-ATPase subunit Rpn8, is an enzyme that in humans is encoded by the PSMD7 gene. In 26S proteasomes is multicatalytic proteinase complex with a very ordered structure ...

                                               

PYCARD

PYCARD, often referred to as ASC, is a protein that in humans is encoded by the PYCARD gene. It is localized mainly in the nucleus of monocytes and macrophages. In case of pathogen infection, however, it relocalizes rapidly to the cytoplasm, peri ...

                                               

RBBP6

The retinoblastoma tumor suppressor pRB protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene enco ...

                                               

RGS11

Regulator of G-protein signaling 11 is a protein that in humans is encoded by the RGS11 gene. The protein encoded by this gene belongs to the RGS controller b signaling protein family. Family members of the CSG as GTP-ASE-activating proteins from ...

                                               

RHBDF1

Inactive rhomboid protein 1 also known as rhomboid 5 homolog 1 or rhomboid family member 1 is a protein that in humans is encoded by the RHBDF1 gene. The alternative name iRhom1 has been proposed, in order to clarify that it is a catalytically in ...

                                               

RNF40

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart sug ...

                                               

RPGRIP1L

The protein encoded by this gene is localized to primary cilia and centrosomes in ciliated human epithelial kidney cells and retinal pigment epithelial cells. RPGRIP1L colocalized at the basal body-centrosome complex with the proteins NPHP4, NPHP ...

                                               

SEPT1

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibril ...

                                               

SEPT12

This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants en ...

                                               

SF3B3

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene. This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3A and a 12S RNA unit, forms the U2 sm ...

                                               

SH2B1

Variations close to or in the SH2B1 gene have been found to associatate with obesity in two very large genome wide association studies of body mass index BMI. Furthermore, SH2B1 deletions are associated with severe early-onset obesity.

                                               

SIAH1

This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog SIAH family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of t ...

                                               

Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B is a protein in humans that is encoded by the SLX1B gene. This gene encodes a protein that is an important regulator of genome stability. Protein is a catalytic subunit in the SLX1-SLX4 struc ...

                                               

SNTB2

Dystrophin is a large, rod-like cytoskeletal protein found at the inner surface of muscle fibers. Dystrophin is missing in Duchenne Muscular Dystrophy patients and is present in reduced amounts in Becker Muscular Dystrophy patients. The protein e ...

                                               

Sodium-chloride symporter

The sodium-chloride symporter is a cotransporter in the kidney which has the function of reabsorbing sodium and chloride ions from the tubular fluid into the cells of the distal convoluted tubule of the nephron. It is a member of the SLC12 cotran ...

                                               

Sodium-glucose transport proteins

Sodium-dependent glucose cotransporters are a family of glucose transporter found in the intestinal mucosa of the small intestine and the proximal tubule of the nephron. They contribute to renal glucose reabsorption. In the kidneys, 100% of the f ...

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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