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EZH1

In mice, EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair. EZH1 also complements EZH2 in maintaining stem cell identity and executing pluripotency.

                                               

FAM18B1

Family with sequence similarity 18 member B1 is the hypothetical protein encoded by the gene LOC51030. Evidence for this protein only exists at the transcript level. The gene is found on chromosome 17 on the cytogenetic band 17p11.2. This gene ha ...

                                               

FAM134C

Model organisms have been used in the study of FAM134C function. A conditional knockout mouse line, called Fam134c tm2aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project ...

                                               

FBXW10

F-box/WD repeat-containing protein 10 is a protein that in humans is encoded by the FBXW10 gene. Members of the f-box protein family, such as FBXW10, characterized by approximately 40-amino acid f-box motif. SCF complexes, formed by SKP1 MIM 6014 ...

                                               

FGF11

Fibroblast growth factor 11 also known as FGF11 is a human gene. The protein encoded by this gene is a member of the intracellular fibroblast growth factor family.

                                               

FLII

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene. This gene encodes a protein with a gelsolin-like actin binding domain and the N-terminal leucine-rich repeat-protein interaction domain. Protein similar to Dros ...

                                               

FLOT2

Flotillin-2 is a protein that in humans is encoded by the FLOT2 gene. Flotillin 2 is a highly conserved protein isolated from caveolae/lipid raft domains that tether growth factor receptors linked to signal transduction pathways. Flot-2 binds to ...

                                               

FMNL1

Formin-like protein 1 is a protein that in humans is encoded by the FMNL1 gene. This gene encodes a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity. An alternative splice varia ...

                                               

Folliculin

Folliculin also known as FLCN, Birt-Hogg-Dube syndrome protein or FLCN_HUMAN is a protein that in humans is associated with Birt-Hogg-Dube syndrome and hereditary spontaneous pneumothorax. It is encoded by the Folliculin gene that acts as a tumor ...

                                               

FOXK2

Forkhead box protein K2 is a protein that in humans is encoded by the FOXK2 gene. The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind with the Purine-rich motifs of the HIV long terminal repeat LTR, and ...

                                               

FOXN1

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and ...

                                               

Fructosamine-3-kinase

FN3K catalyzes phosphorylation of fructosamines formed by glycation, the nonenzymatic reaction of glucose with primary amines followed by Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and re ...

                                               

FSCN2

Fascin-2 is a protein that in humans is encoded by the FSCN2 gene. This gene encodes a family member of the same protein. Fascins cross-linking actin into filamentous bundles within dynamic cell extensions. This family member suggested to play a ...

                                               

FTSJ3

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene. Although the function of this gene is unknown, the existence of this gene is supported by mRNA and data are. A possible function of the encoded protein ca ...

                                               

FXR2

The protein encoded by this gene is an RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may s ...

                                               

G6PC

Glucose-6-phosphatase, catalytic subunit is an enzyme that in humans is encoded by the G6PC gene. Glucose-6-phosphatase is an integral membrane protein of the endoplasmic reticulum that catalyzes the hydrolysis of D-glucose 6-phosphate D-glucose ...

                                               

G6PC3

This gene encodes the catalytic subunit of glucose 6-phosphatase G6Pase. G6Pase is located in the endoplasmic reticulum ER and catalyzes the hydrolysis of glucose 6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glyc ...

                                               

GABARAP

Gamma-aminobutyric acid A receptors are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABAA receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence simila ...

                                               

Galectin-9

Galectin-9 was first time isolated from mouse embryonic kidney in 1997 as a 36 kDa beta-galactoside lectin protein. Human galectin-9 is encoded by the LGALS9 gene.

                                               

GAS7

Growth arrest-specific protein 7 is a protein that in humans is encoded by the GAS7 gene. Growth arrest specific 7 is expressed primarily in the terminal differentiated brain cells and predominantly in Mature Purkinje neurons of the cerebellum. G ...

                                               

Gem-associated protein 4

The product of this gene is part of the SMN protein complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies gems. The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spl ...

                                               

GGA3

ADP-ribosylation factor-binding protein GGA3 is a protein that in humans is encoded by the GGA3 gene. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding family of GGA. This family includes the ubiquitous ...

                                               

GIT1

ARF GTPase-activating protein GIT1 is an enzyme that in humans is encoded by the GIT1 gene. GIT1 contains an ARFGAP domain, Anykrin repeats, and GRK-interacting domain. ARF-gap domain, which allows it to act as the activation of the GTP-Aza gap p ...

                                               

GLUT4

Glucose transporter type 4, also known as solute carrier family 2, facilitated glucose transporter member 4, is a protein encoded, in humans, by the SLC2A4 gene. GLUT4 is the insulin-regulated glucose transporter found primarily in adipose tissue ...

                                               

Glycoprotein IIb/IIIa

In medicine, glycoprotein IIb/IIIa is an integrin complex found on platelets. It is a receptor for fibrinogen and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a r ...

                                               

GNA13

The GNA13 gene encodes the G 13 G protein alpha subunit. Together with GNA12, these two proteins comprise one of the four classes of heterotrimeric G protein alpha subunits. Heterotrimeric G proteins function in transducing hormone and neurotrans ...

                                               

GNGT2

Guanine nucleotide-binding protein G/G/G subunit gamma-T2 is a protein that in humans is encoded by the GNGT2 gene. Phototransduction in rod and cone photoreceptors is regulated by groups of signaling proteins. The encoded protein plays a crucial ...

                                               

GOSR1

Golgi SNAP receptor complex member 1 is a protein that in humans is encoded by the GOSR1 gene. This gene encodes a membrane protein that transportorul trafficking of proteins from the endoplasmic reticulum and the Golgi and between Golgi compartm ...

                                               

GOSR2

This gene encodes a trafficking membrane protein which transports proteins among the medial- and trans-Golgi compartments. Due to its chromosomal location and trafficking function, this gene may be involved in familial essential hypertension. Thr ...

                                               

GPS1

COP9 signalosome complex subunit 1 is a protein that in humans is encoded by the GPS1 gene. This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity w ...

                                               

GRAP

GRB2-related adapter protein is a protein that in humans is encoded by the GRAP gene. This gene encodes a member of the GRB2 / Sem5, the C. elegans homolog / DRK Drosophila homologue of the family. This element performs the function of cytoplasmi ...

                                               

Growth hormone 1

Growth hormone 1, also known as pituitary growth hormone or simply as growth hormone or somatotropin, is a protein that in humans is encoded by the GH1 gene. The protein encoded by this gene is a member of the somatotropin / prolactin family of h ...

                                               

GSDMB

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding differen ...

                                               

H3F3B (gene)

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones form an octamer, around which approximately 146 bp of DNA is wrapped in ...

                                               

HIG1 hypoxia inducible domain family member 1B

This gene encodes a member of the hypoxia inducible gene 1 HIG1 domain family. The encoded protein is localized to the cell membrane and has been linked to tumorigenesis and the progression of pituitary adenomas. Alternative splicing results in m ...

                                               

Histone deacetylase 5

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by th ...

                                               

HN1 (gene)

Hematological and neurological expressed 1 protein is a protein that in humans is encoded by the HN1 gene. Note: HN1 can also contact the notch 1 gene.

                                               

HS3ST3A1

Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 is an enzyme that in humans is encoded by the HS3ST3A1 gene. Heparansulfate biosynthetic enzymes are key components in the creation of many different heparansulfate thin structures that perform ...

                                               

HS3ST3B1

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out ...

                                               

HSD17B1

17β-Hydroxysteroid dehydrogenase 1 is an enzyme that in humans is encoded by the HSD17B1 gene. This enzyme oxidizes or reduces the C17 hydroxy/keto group of androgens and estrogens and hence is able to regulate the potency of these sex steroids

                                               

IFT20

Intraflagellar transport protein 20 homolog is a protein that in humans is encoded by the IFT20 gene. The gene is composed of 6 exons and is located on human chromosome 17p11.1. This gene is expressed in human brain, lung, kidney and pancreas, an ...

                                               

IGF2BP1

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene. This gene encodes a member of the IGF-II mRNA-binding protein IMP of the family. The protein encoded by this gene contains four K homo ...

                                               

IGFBP4

This gene is a member of the insulin-like growth factor binding protein IGFBP family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors IGFs I and II and circulates in ...

                                               

Integrin beta 3

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin bet ...

                                               

Integrin beta 4

Integrins are heterodimers composed of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specifi ...

                                               

ITGAE

Integrin, alpha E also known as CD103 is an integrin protein that in human is encoded by the ITGAE gene. CD103 binds integrin beta 7 to form the complete heterodimeric integrin molecule αEβ7, which has no distinct name. The αEβ7 complex is often ...

                                               

JMJD6

This gene encodes a nuclear protein with a JmjC domain. JmjC domain-containing proteins belong to the alpha-ketoglutarate-dependent hydroxylase superfamily. They are predicted to function as protein hydroxylases or histone demethylases. This prot ...

                                               

KAT7 (gene)

Histone acetyltransferase KAT7 is an enzyme that in humans is encoded by the KAT7 gene. It specifically acetylates H4 histones at the lysine12 residue and is necessary for origin licensing and DNA replication. KAT7 associates with origins of repl ...

                                               

Keratin 9

Keratin 9 is a protein that in humans is encoded by the KRT9 gene. Keratin 9 is a type I cytokeratin. It is found only in the terminal differentiated epidermis of palms and soles. Mutations in the gene encoding this protein cause epidermolytic Pa ...

                                               

Keratin 10

Keratin, type I cytoskeletal 10 also known as cytokeratin-10 or keratin-10 is a protein that in humans is encoded by the KRT10 gene. Keratin 10 is a type I keratin.

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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