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SGCA

The dystrophin-glycoprotein complex DGC comprises a group of proteins that are critical to the stability of muscle fiber membranes and to the linking of the actin cytoskeleton to the extracellular matrix. Components of the DGC include dystrophin ...

                                               

SGSH

A number sign # is used with this entry because the phenotype is caused by mutation in the gene encoding N-sulfoglucosamine sulfohydrolase SGSH, MIM 605270. The Sanfilippo syndrome, or mucopolysaccharidosis III, is a lysosomal storage disease due ...

                                               

Sirtuin 7

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet ...

                                               

SKAP1

Src kinase-associated phosphoprotein 1 is an adapter protein that in humans is encoded by the SKAP1 gene. This gene encodes T cell protein-adapter, class of intracellular molecules with modular Domains capable set of additional proteins, but whic ...

                                               

SKIP

This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Al ...

                                               

SLC13A5

Solute carrier family 13, member 5 also known as the Na + /citrate cotransporter or mIndy is a protein that in humans is encoded by the SLC13A5 gene. It is the mammalian homolog of the fly Indy.

                                               

Slp adaptor and csk interacting membrane protein

This gene encodes a transmembrane adaptor protein that is expressed in antigen-presenting cells and is localized in the immunologic synapse. The encoded protein is involved in major histocompatibility complex class II signal transduction and immu ...

                                               

SMARCD2

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 is a protein that in humans is encoded by the SMARCD2 gene. The protein encoded by this gene is a member of the family of ISO / SNF proteins, whose memb ...

                                               

SMG6

Telomerase-binding protein EST1A is an enzyme that in humans is encoded by the SMG6 gene on chromosome 17. It is ubiquitously expressed in many tissues and cell types. The C-terminus of the EST1A protein contains a PilT N-terminus domain. This st ...

                                               

SMYD4

Model organisms have been used in the study of SMYD4 function. A conditional knockout mouse line, called Smyd4 tm1aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ...

                                               

SNF8

Model organisms have been used in the study of SNF8 function. A conditional knockout mouse line, called Snf8 tm1aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ge ...

                                               

SOCS3

Suppressor of cytokine signaling 3 is a protein that in humans is encoded by the SOCS3 gene. This gene encodes a member of the STAT-induced STAT inhibitor, also known as suppressor of cytokine signaling, family. SSI family members are cytokine-in ...

                                               

SOCS7

Model organisms have been used in the study of SOCS7 function. A conditional knockout mouse line, called Socs7 tm1aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ...

                                               

Sodium-hydrogen antiporter 3 regulator 1

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1. It is also known as ERM Binding Protein 50 or Na+/H+ Exchanger Regulatory Factor. It is believed to interact via long-ran ...

                                               

SPACA3

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.

                                               

Sperm-associated antigen 5

Sperm-associated antigen 5 is a protein that in humans is encoded by the SPAG5 gene. This gene encodes a protein associated with the spindle apparatus of mitosis. The encoded protein may be involved in the functional and dynamic regulation of mit ...

                                               

Sperm-associated antigen 9

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different ...

                                               

Sphingosine kinase 1

Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. Sphingosine 1 fosfauriliruet sphingosine to sphingosine-1-phosphate S1P in sk1 acts normally cytosolic protein but is recruited membranes rich in phosphatidate PA, the ...

                                               

SPOP

Speckle-type POZ protein is a protein that in humans is encoded by the SPOP gene. Disambiguation: For the animated series see She-Ra: Princess of Power. For the Singaporean singing competition, see SPOP Sing! This gene encodes a protein that can ...

                                               

SSH2

For the SSH-2 protocol, see Secure Shell#Version 2.x Protein phosphatase slingshot homolog 2 is an enzyme that in humans is encoded by a gene SSH2. ADF actin depolymerisation factor / cofilin family, see MIM 601442 consists of stimulus-responsive ...

                                               

Star related lipid transfer domain containing 3

StAR related lipid transfer domain containing 3 is a protein that in humans is encoded by the STARD3 gene. STARD3 also known as metastatic lymph node 64 protein is a late endosomal integral membrane protein involved in cholesterol transport. STAR ...

                                               

STAT5B

Signal transducer and activator of transcription 5B is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available.

                                               

STX8

Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. Th ...

                                               

SUZ12

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by ...

                                               

Synergin gamma

This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act ...

                                               

TAC4

Tachykinin-4 is a protein that in humans is encoded by the TAC4 gene. This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are split into small, secreted peptides that activate members of a family ...

                                               

TADA2L

Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins ar ...

                                               

TAF15

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID TFIID, which binds to the core promoter to position the polymerase pr ...

                                               

TBC1D3

TBC1 domain family member 3E/3F is a protein that in humans is encoded by the TBC1D3F gene. This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC domain, which is found in proteins involved in GT ...

                                               

TBCD

Cofactor D is one of four proteins cofactors A, D, E, and C involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin inter ...

                                               

TEKT1

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis a ...

                                               

Telethonin

Telethonin, also known as Tcap, is a protein that in humans is encoded by the TCAP gene. Telethonin is expressed in cardiac and skeletal muscle at Z-discs and functions to regulate sarcomere assembly, T-tubule function and apoptosis. Telethonin h ...

                                               

Thymidine kinase 1

Thymidine kinase 1, soluble, is a human thymidine kinase. Two forms of this protein have been identified in animal cells, in the cytosol and in the mitochondria. The activity of the cytosolic enzyme is high in proliferating cells and peaks during ...

                                               

TIMP2

Tissue inhibitor of metalloproteinases 2 is a gene and a corresponding protein. The gene is a member of the TIMP gene family. The protein is thought to be a metastasis suppressor.

                                               

TLK2

The Tousled-like kinases, first described in Arabidopsis, are nuclear serine/threonine kinases that are potentially involved in the regulation of chromatin assembly. These are different from other "tousled" varieties, such as flock-of-seagulls, p ...

                                               

TM4SF5

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-su ...

                                               

TMC8

The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane dom ...

                                               

TMEM106A

TMEM106A is a gene that encodes the transmembrane protein 106A in Homo sapiens. It is located at 17q21.31 on the plus strand next to cancer-related genes NBR1 and BRCA1. The TMEM106A gene contains a domain of unknown function, DUF1356.

                                               

TNFAIP1

BTB/POZ domain-containing protein TNFAIP1 is a protein that in humans is encoded by the TNFAIP1 gene. This gene was identified as a gene the expression of which may be caused by tumor necrosis factor alpha TNF in human umbilical vein endothelial ...

                                               

TOB1

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphoryla ...

                                               

TOP3A

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass thro ...

                                               

TRAF4

TNF receptor-associated factor 4 also known as RING finger protein 83 is a protein that in humans is encoded by the TRAF4 gene. TRAF4 is a member of the TNF receptor associated factor traf family, a family of scaffold proteins. Traf proteins conn ...

                                               

Transmembrane activator and CAML interactor

Transmembrane activator and CAML interactor, also known as tumor necrosis factor receptor superfamily member 13B is a protein that in humans is encoded by the TNFRSF13B gene. TNFRSF13B is a transmembrane protein of the TNF receptor superfamily is ...

                                               

TRIM25

The protein encoded by this gene is a member of the tripartite motif TRIM family grouping more than 70 TRIMs. TRIM proteins primarily function as ubiquitin ligases that regulate the innate response to infection. TRIM25 localizes to the cytoplasm. ...

                                               

TRIM37

This gene encodes a member of the tripartite motif TRIM family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box ...

                                               

TTC19

Tetratricopeptide repeat domain 19, also known as TPR repeat protein 19 or Tetratricopeptide repeat protein 19, mitochondrial is a protein that in humans is encoded by the TTC19 gene. This gene encodes a protein with a tetratricopeptide repeat do ...

                                               

TUBG1

Tubulin, gamma 1 is a protein in humans that is encoded by the TUBG1 gene. This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as t ...

                                               

Tweety family member 2

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene. Members of this family function as chloride channels. The encoded protein functions as a calcium-activated large conductance chloride channel, and may play a role in ...

                                               

UBE2G1

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene. Modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitinatio ...

                                               

UBE2O

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene. UBE2O functions in the process of erythroid terminal differentiation to eliminate universal cellular components in parallel with the abundant synthesis of ...

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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