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Interferon Lambda 4

Interferon lambda 4 is one of the most recently discovered human genes and the newest addition to the interferon lambda protein family. This gene encodes the IFNL4 protein, which is involved in immune response to viral infection. IFNL4 is similar ...

                                               

Interferon-inducible GTPase 5

Interferon-inducible GTPase 5 also known as immunity-related GTPase cinema 1 is an enzyme that in humans is coded by the IRGC gene. It is predicted to behave like other proteins in the p47-GTPase-like and IRG families. It is most expressed in the ...

                                               

Interleukin 11

Interleukin 11 is a protein that in humans is encoded by the IL11 gene. Il-11 is a cytokine and was first isolated in 1990 from bone marrow-derived fibrocyte-like stromal cells. Initially thought to be important for hematopoiesis, in particular f ...

                                               

Interleukin 27 receptor, alpha subunit

In mice, CD4+ helper T-cells differentiate into type 1 Th1 cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 Th2 cells, which are critical for m ...

                                               

Interleukin 28

Interleukin-28 is a cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses, including the induction of an "antiviral state" by turning on Mx proteins, 2.5-oligoadenylate synthetase as well as IS ...

                                               

ITPKC

ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase. This gene that has been associated with Kawasaki disease. Kawasaki disease is an acute febrile illness that involves the inflammation of blood vessels throughout th ...

                                               

IZUMO1

Izumo sperm-egg fusion 1 is a protein that in humans is encoded by the IZUMO1 gene. In mammalian fertilisation, IZUMO1 binds to its egg receptor counterpart, Juno, to facilitate recognition and fusion of the gametes.

                                               

Kaptin (actin binding protein)

Model organisms have been used in the study of KPTN function. A conditional knockout mouse line, called Kptn tm1aEUCOMMWtsi was generated as part of the International Knockout Mouse Consortium program - a high-throughput mutagenesis project to ge ...

                                               

KCTD15

Potassium channel tetramerisation domain containing 15 also known as BTB/POZ domain-containing protein KCTD15 is protein that in humans is encoded by the KCTD15 gene.

                                               

KDM4B

Lysine-specific demethylase 4B is an enzyme that in humans is encoded by the KDM4B gene. KDM4B belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily.

                                               

KIR2DL4

Killer cell immunoglobulin-like receptors KIRs are transmembrane glycoproteins expressed by natural killer cells and subsets of CD8+ T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13. ...

                                               

KIR3DL3

Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene. Killer cell immunoglobulin-like receptors Kirs are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Kir ...

                                               

KIRREL2

Kin of IRRE-like protein 2, also known as NEPH3, is a protein that in humans is encoded by the KIRREL2 gene. It is primarily expressed in β cells of the pancreatic islets. KIRREL2 is a member of the neph protein family, which includes NEPH2 NEPH1 ...

                                               

KLC3

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain KHC and two kinesin light chain KLC molecules. KLC ...

                                               

KLK1

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikre ...

                                               

KLK4

Kallikrein-related peptidase 4 is a protein which in humans is encoded by the KLK4 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcin ...

                                               

KLK5

Kallikrein-related peptidase 5, formerly known as stratum corneum tryptic enzyme, is a serine protease expressed in the epidermis. In humans it is encoded by the KLK5 gene. This gene is one of the fifteen kallikrein subfamily members located in a ...

                                               

KLK6

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gen ...

                                               

KLK7

Kallikrein-related peptidase 7 is a serine protease that in humans is encoded by the KLK7 gene. KLK7 was initially purified from the epidermis and characterised as stratum corneum chymotryptic enzyme. It was later identified as the seventh member ...

                                               

KLK9

KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues. KLK9 is primarily expressed in thymus, testis, spinal cord, cerebellum, trachea, mammary gland, prostate, brain, salivary gland ...

                                               

KLK10

Kallikrein-10 is a protein that in humans is encoded by the KLK10 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcinogenesis and some ...

                                               

KLK11

Kallikrein-11 is a protein that in humans is encoded by the KLK11 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcinogenesis and some ...

                                               

KLK12

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcinogenesis and some ...

                                               

KLK14

Kallikrein-14 is a protein that in humans is encoded by the KLK14 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcinogenesis and some ...

                                               

KLK15

Kallikrein-15 is a protein that in humans is encoded by the KLK15 gene. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are involved in carcinogenesis and some ...

                                               

LAIR2

Leukocyte-associated immunoglobulin-like receptor 2 is a protein that in humans is encoded by the LAIR2 gene. The protein encoded by this gene is a member of the superfamily of immunoglobulins. Revealed its similarity to LAIR1, an inhibitory rece ...

                                               

Latrophilin 1

Latrophilin 1 is a protein that in humans is encoded by the ADGRL1 gene. It is a member of the adhesion-GPCR family of receptors. Family members are characterized by an extended extracellular region with a variable number of protein domains coupl ...

                                               

LDL receptor

The Low-Density Lipoprotein Receptor is a mosaic protein of 839 amino acids that mediates the endocytosis of cholesterol-rich LDL. It is a cell-surface receptor that recognizes the apoprotein B100, which is embedded in the outer phospholipid laye ...

                                               

LGALS13

It is composed of two identical subunits which are held together by disulfide bonds. The monomer of this protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family, but it could not bind beta-galacto ...

                                               

LIG1

DNA ligase 1 is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase I is the only known eukaryotic DNA ligase involved in DNA replication and repair, making it the most studied of the ligases.

                                               

LIGHT (protein)

LIGHT, also known as tumor necrosis factor superfamily member 14, is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator, as well as decoy receptor 3.

                                               

LILRA4

Leukocyte immunoglobulin-like receptor subfamily A member 4 is a protein that in humans is encoded by the LILRA4 gene. This gene encodes the immunoglobulin-like cell surface protein predominantly expressed in plasmacytoid dendritic cells PDCs. Th ...

                                               

LILRB5

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene. This gene is a member of the leukocyte immunoglobulin-like receptor family Lear, which is located in a gene cluster at chromoso ...

                                               

LIM2

Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene. Lens mammalian cell membranes fiber contains 5 major proteins ranging from 70 KDA to 19 KDA. The specific functions of these proteins is unknown. Some ...

                                               

LRG1

The leucine-rich repeat LRR family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed during granulocyte differentiation. LRG1 has ...

                                               

LRRC8E

Leucine-rich repeat-containing protein 8E is a protein that in humans is encoded by the LRRC8E gene. Researchers have found out that this protein, along with the other LRRC8 proteins LRRC8A, LRRC8B, LRRC8C, and LRRC8D, is sometimes a subunit of t ...

                                               

LSM4

U6 snRNA-associated Sm-like protein LSm4 is a protein that in humans is encoded by the LSM4 gene. And SM-like proteins were discovered in various organisms based on sequence homology with the family of cm SNRPD2 protein, MIM 601061. Sm-like prote ...

                                               

LSM7

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family see SNRPD2, MIM 601061. Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable ...

                                               

Luteinizing hormone beta polypeptide

Luteinizing hormone subunit beta also known as lutropin subunit beta or LHβ is a polypeptide that in association with an alpha subunit common to all gonadotropin hormones forms the reproductive signaling molecule luteinizing hormone. In humans it ...

                                               

MAP2K2

Dual specificity mitogen-activated protein kinase 2 is an enzyme that in humans is encoded by the MAP2K2 gene. It is more commonly known as MEK2, but has many alternative names including CFC4, MKK2, MAPKK2 and PRKMK2.

                                               

MAP2K7

Dual specificity mitogen-activated protein kinase 7, also known as MAP kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase family. The MKK7 protein exists a ...

                                               

MAP3K10

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase funct ...

                                               

MAP4K1

Mitogen-activated protein kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene. It is also known as HPK1. The protein has been shown to play a role in JNK activation.

                                               

MARCH2

E3 ubiquitin-protein ligase MARCH2 is an enzyme that in humans is encoded by the MARCH2 gene. It is a member of the MARCH family of E3 ligases, and plays an important role in the turnover of membrane proteins.

                                               

MARK4

MAP/microtubule affinity-regulating kinase 4 is an enzyme that in humans is encoded by the MARK4 gene. MARK4 belongs to the family of serine/threonine kinases that phosphorylate microtubule-associated proteins causing their detachment from microt ...

                                               

MBOAT7

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 is an enzyme that in humans is encoded by the MBOAT7 gene. It is homologous to other membrane-bound O-acyltransferases.

                                               

MEX3D

MEX3D is an RNA binding protein that interacts with AU-rich elements of Bcl-2. Upon binding, MEX3D has a negative regulatory action on Bcl-2 expression at the posttranscriptional level.

                                               

MiR-27

miR-27 is a family of microRNA precursors found in animals, including humans. MicroRNAs are typically transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. The excised region or, ...

                                               

MiR-150

miR-150 is a family of microRNA precursors found in mammals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interfere ...

                                               

MYBPC2

This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone C region of A bands in striate ...

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Pino - logical board game which is based on tactics and strategy. In general this is a remix of chess, checkers and corners. The game develops imagination, concentration, teaches how to solve tasks, plan their own actions and of course to think logically. It does not matter how much pieces you have, the main thing is how they are placement!

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